Drug interactions might alter how your drugs function or raise your possibility for serious side effects. This doc isn't going to comprise all feasible drug interactions.
If you're thinking that There's been an overdose, connect with your poison Regulate Heart or get medical treatment at once. Be ready to convey to or present what was taken, the amount, and when it took place. How do I keep and/or throw out Promethazine and Codeine?
The opioid antagonists, naloxone and nalmefene, are certain antidotes for respiratory melancholy resulting from opioid overdose. For clinically major respiratory or circulatory depression secondary to codeine overdose, administer an opioid antagonist. An antagonist really should not be administered during the absence of clinically sizeable respiratory despair. Since the period of opioid reversal is anticipated for being less than the duration of motion of codeine in Promethazine with Codeine Oral Remedy, very carefully keep an eye on the affected individual right up until spontaneous respiration is reliably reestablished.
Promethazine is contraindicated in comatose states, As well as in people identified to get hypersensitive or to have had an idiosyncratic reaction to promethazine or to other
Scientific Factors Fetal/Neonatal Adverse Reactions Extended use of opioid analgesics for the duration of pregnancy for healthcare or nonmedical functions may lead to physical dependence inside the neonate and neonatal opioid withdrawal syndrome Soon immediately after birth.
It's not an entire listing of doable Unwanted side effects. When you observe other Unintended effects not mentioned higher than, Call your medical doctor or pharmacist.
Stay clear of the use of Promethazine with Codeine Oral Option in patients using muscle mass relaxants. If concomitant use is necessary, keep an eye on people for signs of respiratory melancholy Which may be higher than usually envisioned.
Symptoms and signs and symptoms of overdosage with promethazine vary from delicate despair of the central nervous technique and cardiovascular procedure to profound hypotension, respiratory melancholy, unconsciousness and sudden Demise.
Promethazine must be utilized cautiously in people with heart problems or with impairment of liver perform.
To aid protect against withdrawal, your physician could lessen your dose little by little. Withdrawal is much more very likely In case you have applied this medication for a long time (various months) or in superior doses. Convey to your health practitioner or pharmacist at once Should you have withdrawal.
Kids are at larger possibility for major (even lethal) Unwanted side effects, Specially respiration challenges. Communicate with the doctor concerning the dangers more info and benefits of this medication.Cough-and-cold products do not cure colds. Cough because of a common chilly generally won't should be handled with drugs. Inquire your medical doctor or pharmacist about other approaches To ease cough and chilly indicators, for example consuming adequate fluids, utilizing a humidifier, or saline nose drops/spray.
In women with normal codeine metabolism (standard CYP2D6 exercise), the amount of codeine secreted into human milk is lower and dose-dependent. There isn't any information on the results with the codeine on milk output.
Codeine was not mutagenic inside the in vitro bacterial reverse mutation assay or clastogenic while in the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.
Codeine Codeine is surely an opioid agonist somewhat selective to the mu-opioid receptor, but with a Significantly weaker affinity than morphine. The analgesic and antitussive properties of codeine have been speculated to originate from its conversion to morphine.